Immune Globulin Intravenous: Myasthenia Gravis (Acute Exacerbation)

Acute exacerbation of myasthenia gravis with topical imiquimod use.

Imiquimod activates the immune system when applied to a local area. We report a patient with a history of well-controlled myasthenia gravis who was prescribed imiquimod for lentigo maligna. Treatment was halted after 2 weeks when the patient reported itching and irritating sensations in his throat, consistent with previous myasthenia exacerbations. The symptoms improved once imiquimod use was d...

Statin-associated exacerbation of myasthenia gravis.

Immune complexes in myasthenia gravis.

Low levels of circulating immune complexes were detected in 42% of 50 patients with myasthenia gravis. Although a number of these had other associated autoimmune disorders, 30% of patients with no clinical evidence of other disorders were positive in the assays used. The nature of the antigen or antigens in the complexes is not known. However, no binding of alpha-bungarotoxin (a specific probe ...

High-dose intravenous immunoglobulin for myasthenia gravis.

An 7-year-old girl with ocular myasthenia gravis (MG) refractory to prednisolone and anticholinesterase compounds was treated with high-dose intravenous immunoglobulin (IVIg). Ocular symptoms disappeared rapidly by the administration of IVIg 300 mg/kg/day for five consecutive days. Booster infusions of IVIg at an interval of 2 weeks appeared to be effective in maintaining a remission at least a...

Seronegative myasthenia gravis and human immunodeficiency virus infection: response to intravenous gamma globulin and prednisone.

BACKGROUND There are only rare reports of myasthenia gravis complicating human immunodeficiency virus infection. The role of immunomodulatory therapy is unknown. METHODS Case report and literature review. RESULTS The diagnosis of human immunodeficiency virus infection followed that of myasthenia gravis in a 35-year-old man. Clinical and electrophysiological features were diagnostic of gener...